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Medications that inhibit CYP2D6 activity, including paroxetine and quinidine, may possibly cause reduced clearance of oxycodone which could lead to a rise in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in an increase in oxycodone Cmax by 11%, AUC by thirteen%, and t½ elim.Patients must be titrated to soreness r

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